SIMETHICONE

Simethicone is a silicone-based compound designed for the suppression of foam. Seen as a key component of an anti-gas medication in pharmaceutical industries, the simethicone helps in relieving the uncomfortable feeling of being bloated.

This versatile chemical compound are commonly introduced as an active pharmaceutical ingredient, excipient and as a processing aid in various drug making procedures.

Duro Kimia supplies Momentive’s pharmaceutical-grade BC Simethicone antifoam, in an emulsion-based, to help drug formulators deliver high-quality pharmaceutical solutions.

CAS: 8050-81-5

IUPAC: Silicone dioxide; Poly(dimethylsiloxane)

Other terms: Simeticone

Simethicone USP Content (%)30
AppearanceWhite emulsion
PDMS Assay (%)28.0 to 31.6
pH2.0 to 3.5
Heavy Metal Content (ppm)<5

KEY FEATURES

  • Chemically inert
    Doesn’t react with most other ingredients, making it versatile for various formulations

  • Compatibility with aqueous formulations
    Easily dispersible in aqueous media

  • Surface tension reduction
    Simethicone lowers surface tension, causing gas bubbles to merge and burst, reducing foam

  • Versatility in physical and chemical conditions
    Maintains its anti-foaming properties across a wide range of temperatures and pH conditions

  • Versatility in physical and chemical conditions
    Maintains its anti-foaming properties across a wide range of temperatures and pH conditions

  • Suitable for oral applications

APPLICATIONS

  • Antacid production
    As an active ingredient in antacid, used in treatment of gastrointestinal disorders

  • Active ingredient in anti-gas medications
    Used to treat painful built-up of gas in patient’s digestive system – effectively relieves bloating, gas, and discomfort caused by excessive gas in the digestive system

  • Excipient
    Delivers foam control and lubrication in pharmaceutical dosages

  • Processing aid
    Removes foam in bio fermentation and other pharmaceutical manufacturing processes

  • Biotechnology
    Applications such as cell culture fermentations

  • Food and beverage industry
    It is an approved food additive, used to control foam in various food processing applications such as brewing, fermentation, and cooking

  • Veterinary products
    Suppression of ‘frothy bloat’ in cattle, aid to relieving animal gastronomical issues

REGULATORY STATUS AND MANUFACTURING ENVIRONMENT:

  • Full USP Compliant

  • Manufactured as an API in a GMP Certified plant

  • Manufacturing plant is registered with the Medicines & Healthcare products Regulatory Agency (MHRA) in the UK

  • Product is supported by a Drug Master File (DMF) lodged with the US Food & Drug Administration (FDA)

  • The DMF supports compliance to the monograph for Simethicone Emulsion USP

  • Certified as Halal and Kosher

ASSOCIATED SOLUTIONS:

For more information regarding the Simethicone, feel free to contact us via the form below or call us at (+6) 03 7806 1081

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